If the league uses DH in both leagues, than you are probably safe filling your bench with $200k-$250k bench guys and spending $$$ on the starting lineup. In leagues that do not use a DH, I like spending about $2-$3 million on the bench with a good mix of defense, pinch runner, and some SLG%.
Unless your pitchers are Bob Caruthers, Jim Kaat, or Mike Hampton, plan on pinch hitting early and often!