I know I'm kinda late to the game on this thread, but wanted to chime in with my 2 cents.
First off I am very new to HD, but think I have a good grasp on how it works.
I too like it to be as close to real life as possible. With that being said, I think that keeping it at conferences of 12 teams is in the best interest of HD, for conpetitive and simplistic reasons. (I also am not a fan of more days off, I like having a game a day to look forward to. The 2 games/day would be great, but there are just some times during the money I couldn't keep up. Also, fewer days off means more seasons, which I also like).
NOW, with all of that being said I would like to see a few changes made. If it were my call, I would move Utah and Colorado to the Pac-12 (also renaming the conferece the Pac-12 would be a nice face lift). I would move Nebraska to the Big 10 (thus giving them their real life 12 teams). These 2 changes would leave the Big-12 with only 10....to get them back to 12 I would add TCU and Notre Dame to the Big-12. Yes, I know Notre Dame in the Big-12 seems CRAZY, but it makes just as much sense as having them in the Big-10, but at least after these changes, we have a more real life look of the conferences. These changes also leave Hawaii and Fresno St without a home, so you have to keep adjusting. Without going into too much depth put Hawaii in the Big Sky, then move a team like Southern closer to their geographical conference, maybe putting them in place of TCU......and so on from there. A "new conference" might need to be added to have all the real life D-1 teams who are currently D2 in the game make the jump. And when I say new conference I mean one like the WAC which is not currently in the game. Obviously it's a lot more complex than just these changes, there would be several dominoes that would keep falling, but I think getting it closer to real life would be a plus.
Obviously this sucks if you're a coach of a team like Hawaii or Fresno St, as you are now no longer a part of a Major Conference, so that has to be taken into some consideration.
Again this is just my 2 cents (sorry it was somewhat rambling) and I can understand why a lot of people would not be in favor of any changes.
Either way I look foward to playing several seasons of HD, I've had a blast so far!