Interesting discussion. Here is what I do though I may be looking at pitching RP more.
I usually go with more pitchers 13, sometimes 12 or 14.
I always give a RP a day off if they go more than 1 inning or 2 days in a row.
On my bench I have a C and a utility player that subs in at SS, CF, 2B, 3B. plus a 3B/RF AAAA type
I will be trying less P and use RP more often on 1 of my teams.