Here are some open league drafting tips, based on the salary structure and sim engine as of January 2013, for a balanced offense.

Spend <=$25M on a defense.
Spend >=$5M on the offensive line.
Spend <=$2M on special teams.
The starting QB should be >=90 durability, >=70 pass accuracy, >=70 pass stamina, >=50 int.
The RBs should total >=100 run stamina and the top 2 RB should have >=90 durability and >=50 run.
The top 2 WR (or top WR and top TE) should be >=90 durability, >=60 rec stamina, >=60 rec.
Spend $325K each on K and P.

bumped for the new year