If he has two or more fewer players than I have available for use in the game (due to redshirts, academic ineligibility, walkons, injury, etc.)...uptempo always -- I want to try and create a situation where my fresher bodies are on the court against his tiring/tired/very tired defenders. I also want as many possessions as possible so that fouls might also come into play for my opponent's limited bench.
If I have an advantage in athleticism and speed and generally even roster numbers available for both teams, I'll still uptempo...I want the game to have as much of a chance to drift toward the "average" as possible with its random number generations. If I'm at a disadvantage in both ath and speed, I'll be running slowdown because I want to try and create a situation where a few wild RNG's can skew the result. If I have an edge in either Ath OR Spd, but not both, then I have to break things down and look at my starting five vs. the opponent's, my bench vs. the opponent's and try to isolate where I think my best opportunity for advantage lies.