I have found you can run and pass out of any formation . I even ran out of shotgun with a running qb and an wr with amazing running attributes. So I concur with those who previously go with what you are comfortable with but also if you just inherited the team, check a few players formations IQ and you may want to just stick with that formation(s) since it may already be built up. Another alternative is match your personnel to the formation(s) you choosed. Ex lots wr maybe trips or shotgun , balanced =pro or I, etc.