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| The 2005 Buffalo Bills roster is below. Clicking on a tab heading will display the specified set of statistics. All columns may be sorted by clicking the column name. Clicking on an individual player will display the player's career statistics including his time with the 2005 Buffalo Bills. |
| Name | Pos | GP | Tackles | Sacks | Int |
|---|---|---|---|---|---|
| '05 London Fletcher | LB | 16 | 104 | 4 | 1 |
| '05 Nate Clements | CB | 16 | 81 | 0 | 2 |
| '05 Angelo Crowell | LB | 15 | 77 | 3 | 2 |
| '05 Lawyer Milloy | S | 16 | 75 | 1 | 1 |
| '05 Terrence McGee | CB | 15 | 60 | 0 | 4 |
| '05 Aaron Schobel | DE | 16 | 54 | 12 | 1 |
| '05 Troy Vincent | S | 16 | 43 | 0 | 4 |
| '05 Jeff Posey | LB | 16 | 39 | 3 | 0 |
| '05 Tim Anderson | DT | 16 | 27 | 1 | 0 |
| '05 Chris Kelsay | DE | 16 | 26 | 2 | 1 |
| '05 Ryan Denney | DE | 16 | 23 | 4 | 0 |
| '05 Justin Bannan | DT | 16 | 23 | 2 | 0 |
| '05 Eric King | CB | 16 | 23 | 0 | 0 |
| '05 Jabari Greer | CB | 16 | 19 | 1 | 0 |
| '05 Sam Adams | DT | 14 | 15 | 3 | 0 |
| '05 Takeo Spikes | LB | 3 | 11 | 1 | 0 |
| '05 Lauvale Sape | DT | 9 | 7 | 0 | 0 |
| '05 Rashad Baker | S | 14 | 5 | 1 | 1 |
| '05 Coy Wire | S | 13 | 4 | 0 | 0 |
| '05 Ron Edwards | DT | 4 | 4 | 0 | 0 |
| '05 Mario Haggan | LB | 16 | 3 | 0 | 0 |
| '05 Josh Stamer | LB | 16 | 0 | 0 | 0 |
| '05 Jim Leonhard | S | 10 | 0 | 0 | 0 |
| '05 Jason Jefferson | DT | 5 | 0 | 0 | 0 |
| '05 Liam Ezekiel | LB | 2 | 0 | 0 | 0 |
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