After a one-season hiatus, the ACC/Big Ten challenge returns for Season 64. Matchups are given below. Season 65 matchups are the same but with opposite home teams. ACC seeds 3 and 4 (Miami, Maryland), and Big 10 seeds 11 and 12 (Penn St. and Minnesota) were swapped to avoid recent rematches.
Clemson @ Iowa
Michigan State @ North Carolina
Maryland at Wisconsin
Ohio State @ Miami-FL
Duke @ Northwestern
Illinois @ Virginia Tech
Wake Forest @ Indiana
Purdue @ NC State
Georgia Tech @ Michigan
Notre Dame @ Florida State
Boston College @ Minnesota
Penn State @ Virginia