p town - often the best strategy in the game is developed by bucking convention. sometimes, a mistake in the game program will even change something that is considered a forum fact, and many times, forum facts are wrong.
I would consider the use of fatigue over target to be a forum fact. Yet, I would highly recommend using FATIGUE, unless some pretty convincing evidence comes about saying otherwise.
I'd say about a year ago, I set all ten of my teams to target for about a month. The results were somewhat inconclusive, my teams still won about the same number. The biggest issue I saw, was when someone played out his minutes early, he did not come back in, which sometimes caused a sub to get very 'RED' or tired. Also, target handles foul trouble poorly, again, subs getting very red. Another issue, is target does not handle 3rd string players well, usually playing out the second string's minutes prior to letting the third string guy play at all, which might mean the only time 3rd string guys play, is at the end of very competitive games.
Some or all of this may have changed since I last tried it out. Maybe it works great. I will say without a big sample size, and without knowing what you're looking for, it will be hard to tell a big difference.
Hope that helps.