Craig, if it's your Hood team you're talking about (and not an alternate ID team), I truly think running uptempo will put you deep in the hurt locker. You're probably going to run into some depth issues due to foul problems since your defensive ratings aren't that good (truthfully, and I know this is harsh, but they are really quite bad. Horrible might be a better word). If you try to run uptempo, with those staminas, and those defensive ratings, you're going to probably find yourself on the wrong end of a whole lot of blowouts. With that team, and those ratings, you should probably plan on running slowdown most of the time if you want to be successful (I think even normal might be pushing it, except against the really bad Sim teams). Now, granted, it's your team and you coach it as you see fit, but that's just my two cents, take it for what it's worth.
***Edit** Sorry, I misread your initial post. I thought you said even "running" uptempo, when in fact, it was even "against" uptempo. My apologies.***