You can absolutely win with HRs in an OL, but for the most part not with modern sluggers from the 90s and 00s. You need guys from years where the HRs normalize very well. I just made the World Series with a team in AFCS built around 2 Cravaths and the 46 Greenberg. Ruth's cheaper seasons, 23 Cy Williams, 99 Buck Freeman, 22 Tilly Walker, and others also tend to do well. There are also some pretty good HR-normalizing years from the 60s-80s...try 1989 for instance.