Do NOT expect to win against humans with solid records and several seasons of experience in your first season. I'm not saying you won't win...I'm just saying do not expect it.
I learned quickly that this is not a video game which has reasonably equally talented teams. It is a vast mixture of talent and you must learn how the game works. With the new 3.0 engine rolling out, most coaches will be trying to figure it out, but overall, more talent on the roster will likely mean a victory.
Good luck and keep in mind that the GDs Guide to the Game is mostly outdated now, with the release of the 3.0 engine.