IMO, it makes a difference due to perception.
He threw out "Sal Bando" numbers until his contract year(in a time of monster hitting numbers) then blew up for a season. He then went back to Sal Bando for 5 more seasons(during what is considered his prime). Plays one season in a hitter's park, in a contract year, and blows up again. Moves to another hitter's park and 3+ seasons later, he's hitting like a HOFer.
So, essentially, he established himself as Sal Bando. Had a big year(PED), returned to Sal Bando until he went to hitter's parks. Players are punished for suspected PED use and for playing in hitter's parks(Coors effect). That's the perception.