1. By the 16th game
2-4. It's arguable. The 10% PQ astutely mentions is factored into the fatigue numbers we see. 99% is really on pace for 11-12% over RL totals. Generally, I'm not bothered by players (pitchers/hitters) playing down to 90, or 85 in extreme cases, and have seen success doing this. Some owners never let anyone get below 99, though, and see success that way as well. Regardless, the teams that will NOT have to deal with this will likely tend to be the successful ones.