Use all your advanced depth charts to your advantage. If your team is stacked with talent and depth, then it's more difficult to get the weaker FR in the game. If your team is avg or in DIA, then it's easier. Sometimes in DIA, you get blessed by the GD Gods and get a 90/90 guy in your backyard that will be the 3rd best OL on your team so getting him on the field is easy.
Sometimes I've used OL #6-10 in a formation or the worst WR in ND Box or DL #5-7 in nickle or a FR LB in 4-3 at 90% effectiveness. Whatever it takes to get all your players on the field.
You can generally look at a coach's stat sheet and see how many players he's getting in the game. If his stat sheet is very small, then he's playing with low effectiveness settings and probably sucking. If his stat sheet is loaded with 5-6 RBs, 4-5 WRs, 3 TEs...then you know he's using all his players and is taking advantage of the advanced depth charts.