I built several teams for the hit-and-run and speed, selecting for contact rates above .900 and speed ratings of 70 and higher. I set them for "very aggressive" both for hit-and-run and for baserunning.
Most of them did well, but crapped out in the playoffs.
I just went through a sampling of games for a team that won 108 games, and found that the hit-and-run was actually in play only 2.15 times per game.
In a fourth of the games, the team had 0 hit-and-run plays.
The team OBP (counting errors by the defense) was .395 on hit-and-run plays, compared to its .390 OBP for the full season. (The league OBP was .379.)
I didn't count the number of times that the strategy appeared to avoid a DP or actually created a DP, but both instances occurred. In one instance, two runners pulled off a double steal.
In the end, I can't say that the hit-and-run is worth bothering with. The same team would have done as well with the average hit-and-run setting.
I did not, though, attempt to discover if the strategy is better in some parks than in others.