What numbers/settings do you recommend for your regular lineup guys and do you rely on auto rest or drop guys to the bench the moment they show signs of fatigue? Thanks.

A lot of people have a lot of different opinions, and it depends a lot on the strength of your bench. If you have a guy that's 70% as good a hitter/fielder on the bench then I would set it high (98 or 99) but if you have a 200k guy with an OPS+ of 35 as your backup then I might go a bit lower (95 or 96). 

Fielding drops off pretty significantly as soon as you get below 100%. Hitting drops off very gradually. So I will usually set my DH and corner outfielders lower (93-95) and my IF/CF higher (97-98)

I'll put them at 99% if I have enough bench. if the whole team is tired adjust the %.

dropping them yourself depends on how active you are as a manager. If you dont login often let auto-rest do the job. I like to rest them myself but only if I will be there later to bring them back. you could rest them before they tire when you are facing a weak team/pitcher or a bad matchup so you have them healthy when you really need them.

Thanks guys.  Good info.