If you want to measure by economic impact then it's Seattle home to Microsoft, Amazon, Starbucks, Nintendo, Nordstrom, Expedia, REI, Boeing, Zillow, Darigold, Costco, Eddie Bauer, Red Hook & Pyramid Breweries, legalized marijuana, gay marriage, charter schools, & the only active volcano in the lower 48.
Why we don't have all 4 major sports is beyond me but Chris Hanson is working on it!
Also Rainier Beer was founded here but is now owned by Miller Brewing Company.