Another thing that hasn't been mentioned here is fouls. The faster the tempo more possessions more fouls. This creates a couple of effects.
(1) Teams with weaker benches are hurt because not only because their best players are more tired but also because they are more likely to get into foul trouble
(2)Good free throw shooting teams benefit even if both teams have more free throws
(3) Teams that tend to go to the line alot benefit because of the discontinuity caused by the bonus. The first 7 fouls don't necessarily result in free throws where fouls after 7 do. This means teams who get fouled alot get into the bonus faster and have a greater percentage of their plays resulting in free throws (which tend to be the most efficient way to score).
Last season I played uptempo exclusively. This was because I had a deep bench, fast/athletic team, whose top three player at getting to the line were rated A, A- and B+ in FT. I also felt that I was better than, or at least equal to most of the teams I was playing, so I didn't have much to think about around wanting to slow the game down for reversion to the mean purposes.