Generally, you use two pitchers who are lacking in stamina to get you deep into games. Ideally, it's a L/R combination. They have to be last in rotation 4A/4B. It requires some work if you're using 1, 2, 3, 4A/4B because there is the possibility that 1 won't be fully recovered in what is, essentially, a 4 man rotation.
If you have pitchers capable of 50 pitches, it's probably more work than it's worth. Just know your 50 pitch pitcher is only going to give you 3-4 innings and build your bullpen appropriately. I use low stamina guys all the time if their other ratings are good enough.