I agree: Injuries would suck due to roster size. In addition to all the season-ending injuries, how about all of the smaller injuries? Think of your O-line. Hopefully you have, say, 8 guys there. What happens if 1 goes down with a season-ending injury and 2 have short-term injuries. You have no backups! The NFL has 53-man active rosters and a practice squad of 10 players. NCAA teams can have 105-player rosters.
I'm OK with no injuries in this game.