For my teams, it's going to depend on my personnel. I don't play any man defense, so my teams are all pretty flexible, in terms of positioning.
For my FB-press, I'll usually end up with 5 starters, 5 backups, and 2 3-string. The exception is when I have a good shooting, weak defending guard I want to bring off the bench at different spots. Sometimes that kind of guy will be the 2-string at both guards and SF. That maximizes his minutes, and makes it tough for a defense to key in on him without double teams; easier to hide on defense, too. Then each of those positions will have a unique 3-string.
With my zone/press teams, though, I'm often more inclined to maximize minutes for my top 7 or 8. Zone makes it easier to do that. My depth charts for z/p teams often look like what sim wants to do with your lineup. I'll have 2 or 3 backups covering those 5 slots, sometimes based on whether I'm going 2-3 or 3-2. Then I'll set fatigue substitutions, paying attention to stamina and overall quality, to help make sure I usually have at least a couple starters on the floor. For example, if I have a guard backing up both guard spots, I'll often set the better one (especially if he has superior stamina) to getting tired, leaving the other at fairly fresh. This helps me hide freshmen or other projects that aren't ready to be exposed for a lot of minutes.