Have been experimenting with settings and lineups and matchups (R/L...better defensive INF for GB pitchers/lineups, etc.) to try to capitalize on opponents' trending weaknesses. I started to wonder if anyone has ever had much luck adjusting settings according to your opponent's players?

In other words, especially in a progressive, if I know a team is a likely favorite in the division, I want to try to maximize my head-to-head against that team. I'm not asking for all of your in-house secrets--I am just as interested to know if it is possible? How much control do we really have? (Anyone ever completely run the table consistently against an inner-division foe?)

Sure, pitching matchups in key series. If I need to use a spot starter, I try to do that in a game against the other league, preferably against a weaker opponent. ..my lineups are already set LH/RH, but I look for fatigue...

I start a catcher with a great arm against teams that can steal, or plan ahead for teams that can steal. But that’s about it. I just like seeing my record against other teams.

I play matchups often. Saving your best for a key opponent is a good one. Good matchups surely gives you some small advantages but maybe not enough to notice in a short series. Short term stats can be wild.

Sometimes if I have a really good, low-PA or low-IP player, I'll make a point of using him against key opponents in my division (or a wildcard opponent). But the one matchup I know has worked out well is saving a low-PA, high-SB guy for opponents with terrible catchers (and setting him to a 5 for base-stealing aggressiveness). Looking up old stats from a 1984 team, I had Jeff Stone (27 SB, 5 CS, 199 PA, .362 BA real-life) get 41 starts plus 31 PH or PR appearances. He wound up with 58 SB, 5 CS, 52 RS, mostly against the bad catchers. I think he had a few individual 3-game series with 10+ SB.

My most amusing matchup story was 1908 Sammy Strang in a low cap league. In RL he hit .094 with a pile of Walks. I spotted him against high BB pitchers some of whom were fatigued. He had obp over .600 for half the season. eventually it fell to "only" a little above .500