I would go with either Arizona or Wisconsin, but since those 2 would play each other if the seeds held, the odds decrease dramatically.
I don't think Kansas or Notre Dame, from Kentucky's bracket, has quiet enough (although I like ND chances much more than Kansas').
This leads me to the other side of the bracket. Gonzaga is a unknown for me, so I eliminated them. I have heard several pundits like Duke's chances, but I am not choosing them simply because I do not want to see them do it (very scientific!).
That leaves Virginia or Villanova. I've not seen Virginia play. I have, however, seen Villanova in person, and I think they may be undervalued. The big question with them is whether their record is a result of a strong, but not dominate, Big East Conference. Again, several 'experts' seem to believe the Big East is overvalued, and if that is the case, then perhaps so to is Villanova. With all that said, since I am a Big East guy, I am going with Villanova to pull the upset in the finals. Feel free to laugh.