I never try to double two players - but now and then will ILS (if leading scorer) two guys. Since one cant know the effects of game planning, that approach is less risky and reflects some modest assessment of my ability to predict.
Early in the game, a very common strategy against teams with just one good outside scorer was minus 2 or 3 or more and then ILS on the scorer. Over time, the engine was tweaked and that became less effective. Still an okay idea in some cases, in my experience.