yeah, thats a huge point that is often overlooked. even if 95% of coaches dont change lineups, 99% of coaches don't take the time to find the method to the madness of those who DO tinker. OR once said, when he encounters those coaches, he just assumes they are shooting themselves in the foot for him by changing too much, and so he just plays his base setup. well, whether for that reason or another, my experience is the vast majority of coaches do the same thing - just play what they know. its great when you can set your team up ideally to another guy's setup, and he makes no effort to counter yours, and that is almost always the case for those of us who do take the time to tinker with depth charts and the like :)
its definitely not an automatic win like emy said, but if you can pick up a couple points a game, then in the long run, over elimination series (like the NT), you probably wind up with double the championships.