The only dev chat I could find referenced the fact that the more pitches a pitcher has, the harder it is for the batter to guess what's coming. But from experience, check out this guy...
Midre Eusebio. I tried to use him as a 3-4 inning starter, but I overestimated the 30 stamina (and thus overpaid...), but he's much more effective in 2 inning stints than he was when he went 3 or 4 innings (about 40-45 pitch count).