There are lots of strategies to the underlying numbers, but your park/team stats should coexist...not just "hitters in a hitting park" and "pitchers in a pitching park."
I always draft a handful of players (my 2-5 hitters, top 3 starting pitchers and two bullpen guys) and then look at what these guys do best. If the hitters hit homeruns and the pitchers don't give up any, I'll choose a + HR park. If all the hitters hit 1Bs and 2Bs and the pitchers OAVs are low, then I'll look for a + 1B OR + 2B park. If I have hitters who walk and steal bases with pitchers who have higher OAVs, then I'll pick a - 1Bs park to help out the pitchers and make walks/steals more valuable. If I go with great hitters and mediocre pitching (or vice versa), I'll grab a true pitchers park (or vice versa).
The key is to look at what the best players on your team do, and match a park to them. Once you do this, fill out the rest of your team with players that accentuate that ballpark. For example, if you have a + doubles park, search for your remaining players by 2B/100AB#. If you play in a negative singles park, choose pitchers who don't walk people. If you play in a + singles park, get pitchers with lower OAVs and look for high 1B/100AB# who run well.