Sounds like Marco Rubio will officially announce a run for the Presidency this month. Odd that he's tossing away a Senate seat, and one that will be difficult for Republicans to hold without Rubio.
I like Rubio though, he holds the qualities that would be a good President. Very intelligent, good back story (albeit he embellished his family's history), smooth talker, sociable, and actually tries to govern. Tough road to win the Republican nomination as he doesn't hold nearly the campaign infrastructure as some other contenders. He's my best bet to end up as a VP candidate for whomever wins the nomination, and if not he could probably get a cabinet post such as Secretary of State if a Repub wins the Presidency.
Worst case scenario is a John Edwards situation (minus the mistress) in which he throws away a Senate seat (which the opposing party picks up), his party loses the General Election, and then he runs again in 4 years.