More seriously, I think there IS a difference. For Kansas, not really. But take, for instance, real life Memphis or Temple or Xavier last year. If they'd lost to RPI 100 (Rhode Island) or RPI 150 (Stanford/San Jose State) that would be different than RPI 220 (Winthrop/UNC-Wilmington) which is in turn different from those bottom schools (UT Pan Am, Chicago State, Houston Baptist).
Kansas takes a loss to anyone but Rhode Island on that list, it's a serious problem.
But if, for instance, Northwestern had lost their season opener this year to UTPA, that would've almost ended their chances right there. They'd need to beat Wisconsin or Ohio State to make up for it, at least.