I was gonna go with Alabama/Georgia State but they played last night. I think the most interesting might be WI/MI. I see Wisconsin/Ohio State/Michigan State as the same. Somebody has to step forward. Crushing MI Indiana-style would help solidify their standing. RichRod needs to beat one of the top Big 10 teams, and I don't think it's Ohio State this year, to prove he belongs. There are some good games in the SEC, ACC, B12 and even Ohio State/Iowa has some meaning but I like the WI/MI match-up the best.
I don't see why you can't be both.