I went a paltry 10-6 yesterday, losing 3 sweet 16 teams (Gtown, Richmond, Marquette). Sadly enough, I even nailed a couple upsets (Murray State, Northern Iowa).
My wife went 11-5, and she picks largely based on the team nicknames (she has Maryland winning the whole thing). She picked a few upsets - St. Mary's because she hates spiders (Richmond), Northern Iowa (Panthers), and Washington (Huskies).
I'm with mmt0315 on the upset specials for today: Siena beats a wounded Purdue team, and Cornell beats Temple. Also look for Minnesota to oust Xavier.