I've run nothing but FB since I started playing.(Naismith at York and the last 6 seasons at Limestone in D-II). It does matter(players with 0 distro won't take any shots except on offensive putbacks for example), but it really depends on the team as far as how flat you want it.
I generally keep it fairly even across the board, but give my better scorers a bit more distro and also base it off of +/- that the opponent is likely to play and what defense they play like with any distro.
One key after running it for awhile is to make sure that you recruit plenty of BH and SPD, because while FB gives you a better shooting% generally, you also end up with more turnovers than with most offenses, so BH and SPD can help counter that.
I also find it's effective to run it uptempo against a zone so that you beat the zone down the court more often.