Of course it's not going to happen, but someday, somehow a one seed is going to lose, and with just how mediocre the top teams have been this year, why not 2010? I don't think Kansas is the obvious choice though, that would be Syracuse. If folks recall from earlier this year, Syracuse did lose an exhibition to a D-3 team, and were down by 20 to DePaul before storming back to win that game. Plus, there's history there - who doesn't remember Syracuse losing to Vermont in 2004?
However, Taylor Coppenrath isn't coming through that door. Still, I'd love to see it happen.