i think the main story here is by far the fatigue. and i only looked at the game for 30 seconds to make that assessment hence my ignoring of the other issues. but i want to weigh in on the +/- now that its been raised.
as a general rule of thumb, sims take a lot of 3s and the + tends to be the better play when playing as the favorite, which is sort of the standard case for humans past an initial rebuild.
in this specific case, i think a +1 is also in order, very possibly also with a DT on the 100 per guy. a +2 could also be justified. just over 30% of FGA are 3s, that is a 0 to +1 in general in my book, negative is quite a gamble *when you are the favorite and 3pt volatility is perhaps your #1 risk of losing*. i guess i would disagree pretty strongly with everyone who suggested the -, even with a DT on the 100 per guy. its not just about %s, its about the quality of the scorers, and this team's lp scorers are significantly less of a concern than the per scoring. combing that with the fact that this is a game where the OP should be a significant favorite (if his fatgiue management was in order), a +1 or +2 over a - is a pretty clear conclusion to me.