Realistically though just because it did not happen in real life does not mean it couldn't happen. Its just that much more unlikely. A 16 has not beat a 1 but if we played another 300 hundred years I would bet that it would.
Michigan State 69, Alabama State 35 (South regional
first round, 2001) 29-25 halftime lead
Michigan St. went on a 26-0 tear and outscored the Hornets 40-10 after the intermission. Alabama State shot just 13 percent from the field (4-for-30) in the last 20 minutes.
November 3rd, 1978 Duke lost to instate rival Davidson 49-33. Amazingly, Davidson came back from a 31-4 halftime deficit. This is the fewest number of points ever scored in a half of NCAA men's basketball.
December 14, 2009
Bethune-Cookman vs Carver Bible 35-28 at half and 99-55 Final
Bethune outscored Carver 64-27 in the second half
December 30, 2001
LSU vs Nichols State
22-25 at half with Nichols State Winning
LSU then outscores Nichols state 49-10 in the second half and wins 71-35
December 30, 2000
New Mexico vs Texas-El Paso
43-42 Texas-El Paso Winning at half
121-86 Texas-El Paso Wins the game outscoring New Mexico 78-44 in the 2nd half
March 16, 2007
Florida vs Jackson State
Florida winning 41-35 at half
Florida wins 112-68 scoring 71-34 in the second half
There is quite a few games and thats just with a quick look at the last 10+ years.