Thinking DII here....

Let's say your opponent has a starting guard who is something like:

ATH: 75
SPD: 65
DEF: 80
BLK: 30

It seems to me this guy should be pretty good against the guys who "drive to the basket" who use SPD/BH/LP/ATH to score because that is probably opposed by ATH/DEF primarily and then BLK and SPD.

Would he be a weaker defender against 3 point shooters?  Since perimeter players use  primarily SPD and PER doesn't it make sense that the opposed defensive equation  value speed more?

I would think it depends on the +/- setting. A faster defender could probably contest the PER better from a 0 or -1 setting where maybe the slower guard in your example would have more trouble? But you put that same slower guard in a +2 setting then maybe he'll be more successful defending the PER. All things being even though maybe the slow guy is the worst PER defender.