Choose one. Take a look at the most successful teams in DI and I bet that very few, if any, use combo defenses. It's so important to have an IQ edge at DI, especially for a team like Penn that won't be hauling in the blue chip recruits (at first anyway).
The one weakness to getting all those 5 stars is that they leave early and it's difficult to develop an intelligent team. Lower level teams can sometimes take advantage with high IQ's. You can only do that by focusing on one offense and one defense.