For me it depends on the team I'm playing and the matchups as I don't always play slowdown if I'm the underdog. There are several factors I'll consider when deciding to go slowdown or uptempo. If I'm playing a superior team then slowdown would help limit the opposing team's possessions, give my starters more playing time due to less fatigue, and thus give me a puncher's chance if my team is shooting efficiently. Running uptempo against a superior team could be more disastrous as it causes more possessions leading to an increased likelihood of reaching an average outcome, i.e. superior team winning.
Disclaimer: I'm not that good of a coach yet so everything I just said could be complete B.S. LOL!