I have recently scaled back my use of uptempo. In my experience, the sim engine can do weird things with uptempo. That said, you would run fast if you want to increase possessions and draw more fouls. More possessions means more shots which, yes, would mean more rebounds. In the scenario you described, with less stamina and a shorter bench, I would probably go normal.
I also think SB is important. Maybe not more important than defense, but still important. If you play a zone, it's even more important. If your opponent is M2M, look for advantages in Athleticism and Speed to decide how to attack.I tend to not even look at SB when scouting a defense.