I’d go 3-2, with -2 defensive setting as your default. Your personnel is begging for 3-2, IMO, and it’s generally a better defense against most teams anyway (the exception being humans who don’t shoot any 3 pt).
I’d move Hendrickson out of the starting lineup, have him as #2 at both C and PF, he should get around 15 mpg from there. I’d move Matheson in as your SF, Zawlsky up to PF, Russo up to C. Nunez should be backing up PG, SG, SF, and getting ~20 minutes per game to keep them more fresh. Thomas can be your emergency big, Zakes your emergency guard. Smith is bad, don’t play him unless absolutely necessary.
So 3-2, -2; fatigue set to fairly fresh, except as noted
C - Russo (fatigue set to getting tired), Hendrickson, Thomas, empty
PF - Zawlsky, Hendrickson, Thomas, empty
SF - Matheson, Nunez, Zakes, Smith
SG - Aaron (set to getting tired), Nunez, Zakes, Smith
PG - Tang, Nunez, Zakes, Smith
Now you have a good 7 man rotation, with 3 emergency guys available when needed. That’s a very solid zone rotation, IMO.