Hey y'all - I'm about to be playing a team in my conference that has an overall rating about 40 points higher than me, but their power forwards and centers average about 19.5 on D so it seems like I could really go after them. Even in cases where their overall defensive rating is high, is it still worth isolating these weak defenders / upping distro for PF/C or should I approach differently? For context, it's a Sim AI team that always plays M2M D.

attacking the weak links can be very effective.

Make sure to consider DEF rating but also look at SPD/ATH and IQ

For example - a center with DEF of 40 maybe no better on defense that a guy with DEF of 20 if the 20 guy has way better ATH and IQ

Always attack the low d guys against m2m.