You need a place to start... what kind of team are you building? Can you live with allowing some home runs? Are you drafting a lot of range and you can live with higher OAVs? Since there's no AAA you probably want to make use of most of your 25 roster spots, so figure out what balance of SP/RP works. I find that if I have 5 SPs I always end up shuffling one to the 'pen so I am always running a 4-man with a lot of manual moves. Maybe that's OK. But a 3 or 4 man is likely to be more set it and forget it. Remember that your last guy probably won't pitch in the playoffs so he won't need to be quite as good, but don't make him crap either.
Then look at some players and compare their $/IP and see who looks way cheaper than everyone around him. Set HR/9+ to 150, AVG# to under .240, BB9# to under 3, whatever you like and see who stands out.
Lots of 2017-2021 pitchers are good values since they never went through dynamic pricing. But they'll be more HR prone.
Personally I don't like paying for Ks, but if you do, they'll be able to throw more innings.