In my opinion, M2M is the best all-around defense if you can recruit the players for it. That doesn't mean just DE (BLK, ATH, SPD, and RB are also important), but the DE rating is very important.
Press has the big advantage of stressing speed over other ratings, which is also one of the most important factors on offense. By maximizing SPD instead of DE, you get an advantage on both sides of the court.
Zone can be great, but can also drive you nuts. I've had great success with it at lower levels, but I suspect it is hurting me some at the highest D1 level. IMO, It seems to be the most inconsistent of the 3 defenses - completely shutting someone down one game, then getting lit up.