I almost always have problems with managing my pitching, to the point that I don't even try to manage it any more. I simply draft starters I hope I can rely on to give me 6 good innings consistently, with all my relievers on "set up A." I am more successful doing that, than anything else I have tried. In boogerlips 100m league, I went with a 2 man rotation, and set their PC at 70/70, with several of the 85-100 inning very effective starters all at setupA. I figured that if I need a spot start here and there, I'll have it. So far, the team is 8-2, and I have had no fatigue issues. But, i would add that when you commit so much of your pay roll to those 2 starters, you have to pick the right ones, and the right ball park, because if they fizzle, it will be a long season.