For many seasons I ran all my teams with complex platooning-- not only L/R but high BE vs. low control, high power vs. low GB/FB. I stopped because it's awfully expensive to find bench guys that complement all my starters' weaknesses. I honestly didn't see any difference in offensive performance after I quit.
So, based on my unscientific experience and observation, I'd say the answer to green's (1B) is, "no," except for traditional R/L platooning.