I used minute-based substitution patterns this season and I liked being able to manage the minute distribution. As long as it didn't result in tired players being left on the court, I couldn't see a downside to it.
. . . but, in real life a coach would never use this sort of substitution pattern because it has players coming and going constantly, which would ruin the on-court chemistry of each unit, since the players aren't allowed to get into a groove, or get a feel for playing with each other. So, does that lack of cohesion show up in the way the players play in the game? If a player is on the court for just a couple minutes does the engine treat the player as "cold" and if a player is on the court longer does the player "heat up?" And would there be a unit-wide effect for keeping a group of players on the court together for an extended length of time?