I think man2man is much more about speed than a zone. Sure you could have a defender with DEF in the 90s+, but if the man he's guarding is anything around 15+ points better in speed, it could be a significant mismatch (at least for guards and SFs).
Basically it really depends on their speed/athleticism/defense/stamina. Man 2 man requires decent to good ratings in all four of those categories, with no really weak player(s) an opponent can exploit.
Taking a look at Bowling Green, it looks like they could do decent in m2m, given good IQs. However, there are a couple weak points such as their back-up SF's speed, and many of their posts' rebounding would hurt them in individual matchups.