in short, size does not matter at all. it is never a factor in game play.
the longer version is that size only matters in recruit generation. its possible that you could deduce some info about potential from size, but i am not sure. it depends how it was coded, realistically it could go either way. if any young ambitious coach is interested in researching and possibly exploiting the possibility, send me a site mail and we can talk through how to figure it out! we'd simply have to determine if it was just starting ratings that were based on size/weight, or if it was final ratings. and also, if correlations like the def ath correlation were only based on starting ratings, or max/final ratings.