I recently just started playing again after several years of no visiting this website so i forgot alot of stuff I used to know. Right now I am using target mins but i am hating it so far. They keep mass subbing my guys like 2 mins into the game and what not. What are some tips on using by fatigue and how can i get my guaranteed mins out to players using it.

Set your depth chart, set everyone to fairly fresh for fatigue and then tweak from there (you can keep a player in longer by changing him from fairly fresh to getting tired,or move a guy up and down the depth chart to increase/decrease minutes played that way too). Unless you an outlandishly high minutes promise to a non-starter or someone with a horrid stamina, it isn't too hard to get kids their minutes under fatigue. 

Try it for a game and see how you like it and then just keep adjusting the settings until you get to where you like with whichever method you end up using.